The Science

The Science Behind CTRL

The research behind every capsule

CTRL isn't a hopeful blend. Every active earns its place in published human research. Below: what each one does, the strongest finding, and a link to the paper so you can check it yourself.

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01 Amino Acid · The Dopamine Precursor

L-Tyrosine 450 mg

The raw material your brain turns into dopamine. When stress and overstimulation burn through your supply faster than food can replace it, tyrosine restocks the line.

Ingredient shot · L-Tyrosine
Molecular Formula Amino Acid
C9H11NO3
Molar mass181.2 g/mol
RoleDA + NE precursor
Dose450 mg
The Mechanism · Plain English

Your brain builds dopamine from tyrosine in three steps. CTRL delivers step one.

You takeL-Tyrosine
Converts toL-DOPA
BecomesDopamine

Tyrosine → L-DOPA → dopamine & norepinephrine.

Reversed
Stress-Induced Cognitive Decline

A 2015 review of human trials found tyrosine sharpens cognition exactly when the brain is under stress or heavy load, the moment your dopamine runs low.

The landmark review

Jongkees, Hommel, Kühn & Colzato · Journal of Psychiatric Research · 2015 · review of human trials

Across controlled studies, tyrosine restored working memory and mental flexibility under pressure versus placebo, with the biggest gains when dopamine was running low.

View study on PubMed

How it works: the precursor effect

Colzato, Jongkees, Sellaro & Hommel · Neuropsychologia · 2013 · single-dose, placebo-controlled

A single dose improved cognitive flexibility, the ability to switch tasks fast, by topping up the precursor your brain needs to keep making dopamine.

View study on PubMed
02 Green Tea Amino Acid · The Calm Focus Switch

L-Theanine 200 mg

The reason CTRL feels calm, not wired. L-Theanine shifts your brain into relaxed focus and quiets the jittery urge to scroll. No sedation, no crash.

Ingredient shot · L-Theanine
Molecular Formula Amino Acid
C7H14N2O3
Molar mass174.2 g/mol
Found inTea leaves
Dose200 mg
The Landmark Trial · Nobre et al.

At 200 mg, the exact dose in CTRL, alpha brain waves climb.

100%
Baseline
+20%
200 mg

Relative alpha-band EEG activity, single 200 mg dose (Nobre, Rao & Owen, 2008).

+20%
More Alpha Activity

Alpha waves are your brain's calm, ready state, the one meditators train for. The 200 mg dose lifts them with zero drowsiness.

Calm without sedation, at our exact dose

Nobre, Rao & Owen · Asia Pacific Journal of Clinical Nutrition · 2008 · EEG study

L-Theanine significantly raised alpha activity, which the authors say "relaxes the mind without inducing drowsiness." Strongest at the 200 mg dose CTRL uses.

View study on PubMed

Stress & cognition over 4 weeks

Hidese et al. · Nutrients · 2019 · randomized, placebo-controlled

Four weeks of L-Theanine eased stress and improved cognition, including verbal fluency, versus placebo in healthy adults.

View study on PubMed
03 Chelated Mineral · The Nervous System Regulator

Magnesium Bisglycinate 120 mg

Magnesium bound to glycine for gentle, high absorption that's easy on your stomach. It quiets an overexcited nervous system and holds the calm baseline everything else is built on.

Ingredient shot · Magnesium
Molecular Formula Mineral Chelate
C4H8MgN2O4
FormBisglycinate
BenefitHigh absorption
Dose120 mg
The Mechanism · Plain English

Magnesium turns down the overexcitation that keeps a stressed brain from settling.

Acts onNMDA receptors
CalmsOver-excitation
SupportsCalm baseline

Magnesium modulates NMDA-receptor signalling and the body's stress response.

Calmer
Subjective Anxiety & Stress

A 2017 review found magnesium eased subjective anxiety in people prone to it, in line with its role in the stress response.

Magnesium & the stress response

Boyle, Lawton & Dye · Nutrients · 2017 · systematic review

Reviewing controlled studies, the authors found magnesium eased subjective anxiety in vulnerable groups.

View study on PubMed

Why bisglycinate

Magnesium absorption · chelated vs. oxide forms

Bound to glycine, magnesium bisglycinate absorbs well and stays gentle, skipping the laxative effect of cheap oxide forms.

View research on PubMed

Six actives. One capsule. No stimulants.

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04 Adaptogen · The Dopamine Protector

Rhodiola Rosea 200 mg · 3% / 1%

An adaptogenic root standardised to 3% rosavins and 1% salidroside. Where tyrosine builds dopamine, Rhodiola makes it last and eases the fatigue stress leaves behind.

Ingredient shot · Rhodiola Root
Active · Salidroside Adaptogen
C14H20O7
Standardised3% Rosavins
 1% Salidroside
Dose200 mg
The Landmark Trial · SHR-5 Extract

In a placebo-controlled trial, standardised Rhodiola cut stress fatigue and sharpened attention.

Placebo
Fatigue
Rhodiola
Improved

Anti-fatigue & attention improvement over 28 days (Olsson, von Schéele & Panossian, 2009).

28 days
To Measurable Effect

Over four weeks of daily use, the Rhodiola group felt less fatigue and focused better than placebo.

Stress-related fatigue & attention

Olsson, von Schéele & Panossian · Planta Medica · 2009 · randomized, double-blind, placebo-controlled

Standardised Rhodiola (SHR-5) significantly reduced fatigue and improved attention in stressed adults, with a calmer morning cortisol response.

View study on PubMed

How it protects dopamine

Rhodiola & monoamine oxidase · mechanism research

Lab studies show Rhodiola slows monoamine oxidase, the enzyme that breaks dopamine down, so the dopamine you make lasts longer.

View research on PubMed
05 Fat Soluble Vitamin · The Long Term Foundation

Vitamin D3 1000 IU

Not just a bone vitamin. D3 works at the gene level to support dopamine production and mood, so your gains build and hold instead of fading by afternoon.

Ingredient shot · Vitamin D3
Molecular Formula Cholecalciferol
C27H44O
Molar mass384.6 g/mol
Acts asHormone precursor
Dose1000 IU
The Mechanism · Plain English

Vitamin D receptors sit on the same brain regions that make and use dopamine

ActivatesVDR receptors
SupportTH gene expression
SustainsDopamine pathway

Vitamin D supports tyrosine hydroxylase, a rate limiting step in dopamine synthesis.

Linked
D Status & Mood

A meta-analysis of thousands of people tied low vitamin D to higher rates of low mood, underlining its role in healthy brain function.

Vitamin D status & mood

Anglin, Samaan, Walter & McDonald · British Journal of Psychiatry · 2013 · systematic review & meta-analysis

Across studies, lower vitamin D tracked with higher rates of depression, supporting a link between healthy D levels and mood.

View study on PubMed

D3 in the dopamine system

Vitamin D & dopaminergic function · mechanism research

Vitamin D helps regulate the genes and enzymes behind dopamine, which is why it works as a foundation, not a quick hit.

View research on PubMed
06 Active B Vitamin · The Essential Cofactor

Vitamin B6 · P-5-P 5 mg

The small ingredient that powers the big ones. CTRL uses pre-activated P-5-P, the exact cofactor your enzymes need to finish turning tyrosine into dopamine.

Ingredient shot · Vitamin B6
Pyridoxal 5'-Phosphate Active Form
C8H10NO6P
FormP-5-P (active)
RoleEnzyme cofactor
Dose5 mg
The Mechanism · Plain English

P-5-P is the spark plug for the enzyme that turns the dopamine precursor into dopamine

PrecursorL-DOPA
Enzyme + P-5-PAADC
FinishedDopamine

P-5-P is the required cofactor for aromatic L-amino-acid decarboxylase (AADC).

The link
That Completes The Chain

Every neurotransmitter step here, dopamine, serotonin, GABA, runs on B6. The active P-5-P form skips a conversion your body would do itself.

B6 as a neurotransmitter cofactor

Pyridoxal 5'-phosphate & AADC · biochemistry

Pyridoxal 5'-phosphate is the essential cofactor for the enzyme that makes dopamine and serotonin, so active B6 is a prerequisite for the whole pathway.

View research on PubMed

Why the active form

P-5-P vs. pyridoxine · bioavailability

Standard B6 must be converted by the liver first. CTRL uses P-5-P directly, so it's ready the moment it's absorbed.

View research on PubMed
Six ingredients · One capsule

Rebuild, protect, and use your own dopamine.

Precursor, cofactor, protector, and calm, dosed to work together. No stimulants, no caffeine, no crash. Just the chemistry your brain runs on.

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